1)Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China;2)Department of Clinical Laboratory, The Second Affiliated Hospital, Harbin Medical University, Harbin 150000, China;3)Heilongjiang Institute of Basic Medicine, Harbin 150086, China;4)Translational Medicine Research and Cooperation Center of Northern China, Harbin Medical University, Harbin 150081, China;5)Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, Ministry of Education, Harbin 150081, China;6.6)Key Laboratory of Genetically Modified Model Animals of Heilongjiang Province, Harbin 150081, China

This work was supported by grants from the Natural Science Foundation Project of Heilongjiang Province (H2018006), the Education Science Planning Key Project of Heilongjiang Province (GJB1320181), the Higher Education Teaching Reform (Key) Project of Heilongjiang Province (SJGZ20200109), Innovative Scientific Research Fund of the Second Affiliated Hospital of Harbin Medical University (2020) and HMU Marshal Initiative Funding (HMUMIF-21025).