Breast cancer has become the first rank cancer in the world, and the exploration of the pathogenesis and treatment of breast cancer deserves more and more attention. Lipid metabolism dysfunction is one of the most prominent metabolic changes in cancer cells. It is very important to explore the changes of lipid metabolism in breast cancer cells in order to find new diagnostic indicators and therapeutic targets. This paper introduces the research progress of lipid metabolism dysfunction in breast cancer from 4 aspects: (1) the expression of abnormal fatty acid metabolism in breast cancer from three aspects of fatty acid synthesis, oxidation and uptake and the related research progress; (2) introduction to the abnormal expression of triglyceride metabolism in breast cancer from the aspects of triglyceride synthesis and degradation and the related research progress; (3) to introduce the abnormal expression of cholesterol synthase in breast cancer and the related research progress; (4) to introduce the abnormal expression of lipid metabolism signaling pathways in breast cancer from five signaling pathways, namely Notch, Hippo, Hedgehog, Wnt and mTOR, and the related research progress. The aim is to provide new ideas and methods for targeting lipid metabolism in the treatment of breast cancer.