Research Progress on The Relationship Between Microglia Polarization and Depression

doi:10.16476/j.pibb.2021.0199

Home > Archive>Volume 48, Issue 12, 2021 >1404-1413. DOI:10.16476/j.pibb.2021.0199

Research Progress on The Relationship Between Microglia Polarization and Depression
DOI:
                        10.16476/j.pibb.2021.0199
                    
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Affiliation:1) Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical College, Guilin 541199, China;2) Department of Physiology, Hengyang Medical College, University of South China, Hengyang 421001, China;3) School of Pharmacy, Guilin Medical College, Guilin 541199, China;4) Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, Second Affiliated Hospital of Guilin Medical College, Guilin 541199, China;5) Department of Physiology, Basic Medical College, Guilin Medical College, Guilin 541199, China;6.6) General Practice Department, Second Affiliated Hospital of Guilin Medical College, Guilin 541199, China
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Fund Project:This work was supported by grants from The National Natural Science Foundation of China (82060250), the Guangxi Science and Technology Plan Project (AD20238035), the Natural Science Foundation of Hunan Province (2019JJ50541), the Open Project of Guangxi Key Laboratory of Brain and Cognitive Neuroscience (GKLBCN-20190105-02) and the Guangxi Zhuang Autonomous Region Students’ Innovation and Entrepreneurship Training Program of China (202010601050, 202110601010).

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Abstract:

Microglia mainly control the immune efficiency of the central nervous system and play an important role in various psychiatric diseases. Neuroinflammation triggered by the signaling pathway activation is related to the development of depression. Microglia are the main mediators of neuroinflammation. Different stimulations promote the polarization of microglia, which secrete inflammatory cytokines that affect the regulation of neuroinflammation. Clinical and experimental research in vivo and in vitro have demonstrated the relationship of depression with neuroinflammation mediated by microglial polarization. The possible mechanisms of polarization mediating depression involve NF-κB signaling pathway activation, respiratory bursts, complement receptor 3 (CR3) signaling pathway activation, NLRP3 inflammation activation, cannibalism receptor 1 (CB1) activation, Notch-1 signal pathway stimulation, and PPARγ receptor activation. This review discusses research progress on the relationship between microglial polarization and depression.

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WAN Teng, GAO Xue, LIU Shun-Feng, MENG An-Na, Lü Hong-Ying, WU Zhuan, ZHOU Shou-Hong. Research Progress on The Relationship Between Microglia Polarization and Depression[J]. Progress in Biochemistry and Biophysics,2021,48(12):1404-1413

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Received:July 10,2021
Revised:October 26,2021
Accepted:November 09,2021
Online: December 23,2021
Published: December 20,2021

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