1.1)Sino-Portugal TCM International Cooperation Center, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China;2.2)Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences (CAAS), Beijing 100193, China;3.3)Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China;4.4)Department of Critical Care Medicine of Liver Disease, Beijing You-An Hospital, Capital Medical University, Beijing 100069, China;5.5)State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China;6.6)National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing 100094, China;7.7)Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China;8.8)Dr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan

This work was supported by grants from the Opening Foundation of the State Key Laboratory of Space Medicine Fundamentals and Application, Chinese Astronaut Research and Training Center (SMFA18K06), the National Key Research and Development Program of China (2016YFE0131800) and the High-end Talents Recruitment Program (Liu Xinmin group) of Luzhou Municipal People’s Government.