1)College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China;2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China;3)Division of Innovative Medical Research, Chinese PLA General Hospital, Beijing 100853, China
This work was supported by a grant from Research Foundation for Young Teachers of Beijing Technology and Business University(QNJJ2022-27)
As a new type of organoid model, skin organoids can reconstruct and modify different types of cells and appendages with specific functions such as umbilical cord blood stem cells, induced pluripotent stem cells, keratinocytes and fibroblasts, as well as sebaceous glands, sweat gland and hair follicles under special habitats, which can not only highly simulate the physiological structure and function of skin tissues, but also better restoring more realistic skin ecology under different in vitro environments. It can also be used in the fields of skin wound regeneration, skin tumor, immune and metabolic diseases, treatment of inflammatory diseases and drug screening. Meanwhile, skin organoids can not only make up for the deficiencies of existing in vitro skin models in terms of structure and function, but also enable high-throughput screening of drugs or raw materials, reducing the time and economic costs in the later stages of drug screening. However, due to the limitations of current technology, the types and functions of organoids cannot be fully realized to realistically simulate the physiological conditions in the body such as lipid metabolism and blood circulation. Moreover, issues such as consistency and standardization of mass-produced organoids need to be addressed, such as source cells, structure and function, which require the establishment of appropriate standards based on practical applications. Based on this, this paper details the cell sources involved in skin organoids construction and their applications in recent years and several skin appendages like organs that have been constructed and provides an outlook on the future development and optimization of skin organoids.
WANG Min, ZHANG Lin-Feng, XU He-Ran, ZHANG Xiao-Na, HUA Jing-Lin, ZHANG Tian-Tian, ZHAO Feng-Nian, ZHU Zi-Ying. Research Progress in Establishment, Function and Application of Skin Organoids[J]. Progress in Biochemistry and Biophysics,2022,49(10):1961-1973
Copy® 2025 All Rights Reserved ICP:京ICP备05023138号-1 京公网安备 11010502031771号