Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
This work was supported by grants from The National Natural Science Foundation of China (81771352, 81971782) and Tianjin Major Project (15ZXLCSY00040-7).
Deep brain stimulation has become an effective treatment for many neurological and psychiatric conditions. However, invasive electrode implantation carries the risk of surgical complications, and the stimulation target is difficult to change after implantation. Non-invasive stimulation methods such as transcranial magnetic stimulation and transcranial electrical stimulation offer new avenues for modulating brain function. However, these non-invasive brain stimulation methods have not been shown to directly modulate deep brain activity without affecting cortical neurons. Therefore, these methods are mainly used to modulate neural activity in the superficial regions of the brain. Temporal interference (TI) stimulation is a new non-invasive deep brain stimulation method that modulates neural activity through the interaction of two high-frequency electric fields to generate a low-frequency envelope. This approach is expected to address the need for non-invasive deep brain stimulation. This paper first introduces the concept and safety of TI stimulation, and then describes the evoked field analysis methods in the existing research on TI stimulation and discusses the physiological model modeling method and simulation platform related to TI stimulation analysis. Research progress and application progress in animals and humans also were introduced. Finally, based on the current research progress, we proposed future research directions for TI stimulation, to provide new research ideas for non-invasive deep brain stimulation research.
JIA Xiao-Li, HU Nan, WANG You-Wei, LI Xiao-Hong. Electric Field Analysis Progress of Temporal Interference[J]. Progress in Biochemistry and Biophysics,2022,49(10):1935-1944
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