From the creation of the universe to the explosion of life, to intelligent evolution, and to artificial intelligence, this is a long river of evolution. The times are asking, where do the brain and mind come from and where will they go? What is the future and destiny of human civilization? How can brain intelligence and artificial intelligence illuminate each other? Can artificial intelligence lead to the “mind” through a completely different path from biological evolution? How does intellectual creativity evolve into New Quality Productivity? The core of these questions is still how the human brain works as a whole? Here, I will outline a dialectical unity of complexity and simplicity at the micro-meso-macro-cosmological scale.