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核糖代谢失调症

DOI:10.16476/j.pibb.2019.0210

None

DOI:10.16476/j.pibb.2019.0210

参考文献 1
苏涛, 辛亮, 赫英舸, 等. 2型糖尿病患者核糖浓度显著高于正常. 生物化学与生物物理进展, 2013, 40(9):816-825Su T, Xin L, He Y G,et al. Prog Biochem Biophys, 2013, 40(9):816-825
查找原文
参考文献 2
ChenX X, SuT, ChenY, et al. D-ribose as a contributor to glycated haemoglobin.EBioMedicine, 2017, 25:143-153
查找原文
参考文献 3
ChenY, YuL X, WangY J, et al. D-Ribose contributes to the glycation of serum protein. Biochim Biophys Acta Mol Basis Dis, 2019, 1865(9): 2285-2292
查找原文
参考文献 4
YuL X, ChenY, WeiY, et al. D-ribose plays a crucial role in type 1 diabetic encephalopathy. Aging-US, 2019, 11(14): 4943-4968
查找原文
参考文献 5
HanC S, LuY, WeiY, et al. D-ribose induces protein glycation and AGE formation and impairs spatial cognition. 2011,PLoS ONE, 6(9): e24623
查找原文
参考文献 6
HanC S, LuY, WeiY, et al. D-Ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death and Diseases, 2014，5： e1117
查找原文
参考文献 7
WuB B, WeiY, WangY J, et al. Gavage of D-ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget, 2015, 6(33): 34131-342142
查找原文
参考文献 8
LyuJ, YuL X, HeY G, et al. A brief study of the correlation of urine D-ribose with MMSE scores of patients with Alzheimer’s disease and cognitively normal participants. Am J Urol Res, 2019, 4(1): 018-023
查找原文
参考文献 9
ChenY, YuL, WeiY, et al. D-ribose increases triglyceride via upregulation of DGAT in the liver. Sci China Life Sci, 2019, 62(12): 858-861
查找原文
参考文献 10
ZhouY,WangX M,FanS C,et al. A lumbrokinase isozyme targets hepatitis B e-antigen. Sci China Life Sci, 2018, 61(12): 1596-1598
查找原文
参考文献 11
ZhangN, ZhaoS Y, HongJ N, et al. Protective effects of Kaempferol on D-ribose-induced mesangialcell injury. Oxidative Medicine and Cellular Longevity, 2019, 2019: 7564207
查找原文
参考文献 12
HongJ N, WangX M, ZhangN, et al. D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res, 2018, 41(8):838-847
查找原文
参考文献 13
SuT, HeR Q. An insight of D-ribose metabolic imbalance in type 2 diabetes mellitus. Progress in Biochemistry and Biophysics, 2015, 42(4): 390-392
查找原文
目录 contents

    * 第十七次中国暨国际生物物理大会（天津）学会期刊论坛报告概要.

    赫荣乔**

    （中国科学院生物物理研究所，北京 100101）

    核糖代谢失调症(metabolic disorder of ribose,MDR)即由于核糖代谢失调所引起的一系列临床表现，如高尿和高血核糖(hyperribocemia)，伴有或不伴有高尿和高血葡萄糖(hyperglycemia)[1]， 糖化血红蛋白[2]，特别是糖化血清蛋白[3]显著高于正常对照. 动物实验表明，STZ诱导的Ⅰ型糖尿病（T1DM）、Ⅱ型糖尿病（T2DM）大鼠模型及ZDF转基因糖尿病大鼠模型，均具有血和尿核糖水平升高的特点[2,4]. 腹腔注射核糖10 d或30 d，可以观察到小鼠脑内糖基化终末产物(advanced glycation end products,AGEs)的沉积；核糖灌胃180 d，可以观察到小鼠脑内胶质细胞活化、Aβ沉积、Tau蛋白异常磷酸化，同时表现出在Y迷宫和水迷宫模式(Morris water maze)中学习记忆的损害，表现出类似老年认知损害的病理特点[5,6,7]. 临床试验显示，阿尔茨海默病患者(n=49)尿核糖显著高于认知正常对照(n=44)的水平[8]. 另外，腹腔注射核糖可以引起包括肝脏在内的内脏甘油三酯显著升高，如果长期过量摄取核糖可能导致脂肪肝，甚至肝损害[9,10]. 动力学研究显示，核糖糖基化蛋白质的速度显著快于葡萄糖，当核糖浓度仅为葡萄糖的1/50，其糖基化人类血清白蛋白(albumin)的一级速度常数依然是葡萄糖的30倍左右[2]. AGEs是糖尿病并发症的最主要危险因素之一，因此，高血核糖可能导致血中蛋白质的快速糖基化，从而导致血管、肾脏等损害[11,12]. 核糖较容易透过血脑屏障(blood brain barrier,BBB)，从而引起脑内包括海马和皮层在内的结构损害[5,6]. MDR可能的机制是磷酸戊糖循环(pentose phosphate pathway,PPP)代谢失调，同时具有胰岛素缺乏或抵抗[13]. 到目前为止，核糖代谢失调症的发病机制、病理生理、诊断标准，以及干预措施等，还有许多问题需要进一步研究.

  • 参考文献

    • 1

      苏涛, 辛亮, 赫英舸, 等. 2型糖尿病患者核糖浓度显著高于正常. 生物化学与生物物理进展, 2013, 40(9):816-825Su T, Xin L, He Y G,et al. Prog Biochem Biophys, 2013, 40(9):816-825

    • 2

      Chen X X, Su T, Chen Y, et al. D-ribose as a contributor to glycated haemoglobin.EBioMedicine, 2017, 25:143-153

    • 3

      Chen Y, Yu L X, Wang Y J, et al. D-Ribose contributes to the glycation of serum protein. Biochim Biophys Acta Mol Basis Dis, 2019, 1865(9): 2285-2292

    • 4

      Yu L X, Chen Y, Wei Y, et al. D-ribose plays a crucial role in type 1 diabetic encephalopathy. Aging-US, 2019, 11(14): 4943-4968

    • 5

      Han C S, Lu Y, Wei Y, et al. D-ribose induces protein glycation and AGE formation and impairs spatial cognition. 2011,PLoS ONE, 6(9): e24623

    • 6

      Han C S, Lu Y, Wei Y, et al. D-Ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death and Diseases, 2014，5： e1117

    • 7

      Wu B B, Wei Y, Wang Y J, et al. Gavage of D-ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget, 2015, 6(33): 34131-342142

    • 8

      Lyu J, Yu L X, He Y G, et al. A brief study of the correlation of urine D-ribose with MMSE scores of patients with Alzheimer’s disease and cognitively normal participants. Am J Urol Res, 2019, 4(1): 018-023

    • 9

      Chen Y, Yu L, Wei Y, et al. D-ribose increases triglyceride via upregulation of DGAT in the liver. Sci China Life Sci, 2019, 62(12): 858-861

    • 10

      Zhou Y,Wang X M,Fan S C,et al. A lumbrokinase isozyme targets hepatitis B e-antigen. Sci China Life Sci, 2018, 61(12): 1596-1598

    • 11

      Zhang N, Zhao S Y, Hong J N, et al. Protective effects of Kaempferol on D-ribose-induced mesangialcell injury. Oxidative Medicine and Cellular Longevity, 2019, 2019: 7564207

    • 12

      Hong J N, Wang X M, Zhang N, et al. D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res, 2018, 41(8):838-847

    • 13

      Su T, He R Q. An insight of D-ribose metabolic imbalance in type 2 diabetes mellitus. Progress in Biochemistry and Biophysics, 2015, 42(4): 390-392

  • 基本信息

    DOI:10.16476/j.pibb.2019.0210

    引用信息

    .核糖代谢失调症[J].生物化学与生物物理进展,2019,46(09):930-930.

    • image /

  • 参考文献

    • 1

      苏涛, 辛亮, 赫英舸, 等. 2型糖尿病患者核糖浓度显著高于正常. 生物化学与生物物理进展, 2013, 40(9):816-825Su T, Xin L, He Y G,et al. Prog Biochem Biophys, 2013, 40(9):816-825

    • 2

      Chen X X, Su T, Chen Y, et al. D-ribose as a contributor to glycated haemoglobin.EBioMedicine, 2017, 25:143-153

    • 3

      Chen Y, Yu L X, Wang Y J, et al. D-Ribose contributes to the glycation of serum protein. Biochim Biophys Acta Mol Basis Dis, 2019, 1865(9): 2285-2292

    • 4

      Yu L X, Chen Y, Wei Y, et al. D-ribose plays a crucial role in type 1 diabetic encephalopathy. Aging-US, 2019, 11(14): 4943-4968

    • 5

      Han C S, Lu Y, Wei Y, et al. D-ribose induces protein glycation and AGE formation and impairs spatial cognition. 2011,PLoS ONE, 6(9): e24623

    • 6

      Han C S, Lu Y, Wei Y, et al. D-Ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death and Diseases, 2014，5： e1117

    • 7

      Wu B B, Wei Y, Wang Y J, et al. Gavage of D-ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget, 2015, 6(33): 34131-342142

    • 8

      Lyu J, Yu L X, He Y G, et al. A brief study of the correlation of urine D-ribose with MMSE scores of patients with Alzheimer’s disease and cognitively normal participants. Am J Urol Res, 2019, 4(1): 018-023

    • 9

      Chen Y, Yu L, Wei Y, et al. D-ribose increases triglyceride via upregulation of DGAT in the liver. Sci China Life Sci, 2019, 62(12): 858-861

    • 10

      Zhou Y,Wang X M,Fan S C,et al. A lumbrokinase isozyme targets hepatitis B e-antigen. Sci China Life Sci, 2018, 61(12): 1596-1598

    • 11

      Zhang N, Zhao S Y, Hong J N, et al. Protective effects of Kaempferol on D-ribose-induced mesangialcell injury. Oxidative Medicine and Cellular Longevity, 2019, 2019: 7564207

    • 12

      Hong J N, Wang X M, Zhang N, et al. D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res, 2018, 41(8):838-847

    • 13

      Su T, He R Q. An insight of D-ribose metabolic imbalance in type 2 diabetes mellitus. Progress in Biochemistry and Biophysics, 2015, 42(4): 390-392

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