Vol.43,No.9,2016 Other Issues:   Vol.52,2025 Vol.51,2024 Vol.50,2023 Vol.49,2022 Vol.48,2021 Vol.47,2020 2019 Vol.46 2018 Vol.45 2017 Vol.44 2016 Vol.43 2015 Vol.42 2014 Vol.41 2013 Vol.40 2012 Vol.39 2011 Vol.38 2010 Vol.37 2009 Vol.36 2008 Vol.35 2007 Vol.34 2006 Vol.33 2005 Vol.32 2004 Vol.31 2003 Vol.30 2002 Vol.29 2001 Vol.28 2000 Vol.27 1999 Vol.26 1998 Vol.25 1997 Vol.24 1996 Vol.23 1995 Vol.22 1994 Vol.21 1993 Vol.20 1992 Vol.19 1991 Vol.18 1990 Vol.17 1989 Vol.16 1988 Vol.15 1987 Vol.14 1986 Vol.13 1985 Vol.12 1984 Vol.11 1983 Vol.10 1982 Vol.9 1981 Vol.8 1980 Vol.7 1979 Vol.6 1978 Vol.5 1977 Vol.4 1976 Vol.3 1975 Vol.2 1974 Vol.1   Cover Story：Antibody (also named as an immunoglobulin, Ig), a most important macromolecule for immune response in human body, has been developed as macromolecular drug to treat the cancer and immune diseases. Understanding of antibody three-dimensional (3D) structure and fluctuation could be an important step for further understanding and controlling the antibody pharmacological function. However, the study is limited by antibody flexible structure. In this paper, we reviewed the current research progresses on structural study of human IgG1 antibody conducted by our recently developed individual-particle electron tomography (IPET) method. The review includes the sample preparation method, basic logic of image processing strategy, 3D analysis and its application in antibody-drug conjunction and antibody structural fluctuation. We also discussed the strengths and weakness of the technique. Reviews and Monographs Molecular Mechanisms of Histone Phosphorylation in Regulating Learning and Memory LIU Xiao-Ya and GAO Can    [Abstract] [PDF] [HTML] 3D Reconstruction and Structural Study of IgG1 Antibody by Individual-particle Electron Tomography ZHANG Xing, LIAO Yu-Heng, TONG Hui-Min, ZHANG Lei, ZHANG Sheng-Li and REN Gang    [Abstract] [PDF] [HTML] The Structure and Function of Viral Fusion Protein CI Ya-Li, XU Cai-Min and SHI Lei    [Abstract] [PDF] [HTML] The Role of Retromer in Viral Life Cycle LI Ye and ZHANG Lei-Liang    [Abstract] [PDF] [HTML] Selectivity and Mechanism of Polyubiquitin Chain Hydrolases ZHENG Qing-Yun, WANG Tao, PAN Man, LI Yi-Ming and TIAN Chang-Lin    [Abstract] [PDF] [HTML] Research Progress of microRNA in The Pathogenesis of Fragile X Syndrome TIAN Shuai and MA Yun    [Abstract] [PDF] [HTML] Research Papers Spaceflight Microgravity Reduced Photosynthetical Electron Transport and Altered Energy Distribution in Euglena gracilis LI Xiao-Yan, LI Gen-Bao, LI Dun-Hai, HAO Zong-Jie, WANG Gao-Hong, RICHTER R. Peter, SCHUSTER Martin, LEBERT Michael and LIU Yong-Ding    [Abstract] [PDF] [HTML] Characterization of Photosystem I and Photosystem II From Spinach: Effect of Ionic Strength and Impact on Purification WANG Ling-Ling, HUANG Ya-Qi, ZHANG Xue-Fang, QU Jian-Bo and LIU Jian-Guo    [Abstract] [PDF] [HTML] Anticancer Effects of Valproic Acid on Esophageal Stem-like Carcinoma Cells Saboor Maleki,Fatemeh B. Rassouli,MAryam M Matin and Mousavi    [Abstract] [PDF] [HTML] New techniques Bioinformatic Resources and Methods for Glycoproteomics LIU Hang, YAO Jun, YANG Peng-Yuan and ZHANG Yang    [Abstract] [PDF] [HTML]

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